ALS : Autograph Letter SignedAmerican physician who was convinced of the practicality of Edward Jenner's vaccine against smallpox. His work led to the eradication of smallpox in the Americas. Autograph note signed, [after 1814]. Waterhouse writes, "Please to exchange this vol. of Ld. [John Baker-Holroyd, Earl] Sheffield's works of [historian Edward] Gibbon for the 4th." Boldly signed, "B. Waterhouse." An extremely scarce note by the famed Harvard professor and early advocate of vaccination in America. Glue traces at edges, age-toned, otherwise in very good condition. An edition of Gibbon's Miscellaneous Works, edited by Sheffield was first issued in more than three volumes in 1814; volume IV includes his classical and critical works.